Diego Nostromo, once an outlaw terrorizing the byways of the Argentine; now, THRUSH's head of criminal activities in South America.

MEDUSA is a Victorian-era multinational crime and nihilist organization dedicated to conquest and control through terror, conflict and espionage. It was co-founded by Baron Mordant and Lord Khan. Leading the fight against MEDUSA are Great Britain, the French Republic, the Holy Roman Empire and the American Confederation. Also pitted against MEDUSA is THRUSH, a rival criminal syndicate founded in 1875 by Professor James Moriarty and Dr Miguelito Loveless. Both are opposed by the United Network of Countries (UNC)